PAC-Campy

Preventing and combating Campylobacter infections: On track towards a One Health approach

 

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Goal of the consortium

The increasing number of officially registered human cases creates the urgent need for development of novel strategies for prevention, control and treatment of Campylobacter infections.

In the context of the One Health concept, the overall goal of the PAC-Campy consortium is to lower the burden of Campylobacter along the food chain and the incidence of infections in humans.

Working program and structure of the consortium

To achieve this goal, we are using several coordinated lines of research (combined in four research complexes) that are closely linked and complement each other.

Research activities

In the first line, we will focus on establishing and implementing intervention strategies along the poultry production chain (with a specific focus on the farm level) in order to limit pathogen colonisation and spread in affected animals and subsequently reduce the Campylobacter load in chicken meat. Based on these data, a risk intervention model that simulates the impact of the specific interventions will be generated and tested under field conditions to support public health authorities and industry to focus on intervention measures accordingly.

These data are supported by integrative research activities in order to describe the role of the environment for Campylobacter epidemiology by investigating farm emissions into the environment and vice versa, investigate the tenacity of Campylobacter in the environment and identify survival strategies outside the host.

In the second line, we will apply various in vitro assays and mouse models to develop novel therapeutic approaches to combat infection and/or limit post-infectious sequelae in humans to the pharmaceutical and preclinical levels.

These complementary research lines are completed by the development of sensitive and highly specific molecular characterisation techniques that will allow to improve source attribution and outbreak investigations.

Research complexes

 

We have structured the consortium into research complexes that are supported by the work of the individual project partners (IPs). IPs are contributing with different tasks to the corresponding research complexes:

A. Intervention strategies

B. Therapeutic approaches / Bacteria-Host interactions

C. Diagnostics

D. Survival outside host

Coordination

Prof. Dr. med. vet. Thomas Alter

Freie Universität Berlin, Institut für Lebensmittelsicherheit und –hygiene

Berlin

Email: thomas.alter(at)fu-berlin.de

Tel. +49 (0)30 838 62560

 

Prof. Dr. rer. nat. Stefan Bereswill

CharitéUniversitätsmedizin Berlin, Institut für Mikrobiologie und Hygiene,

Berlin

Email: stefan.bereswill(at)charite.de

Tel. +49 (0)30 450 524 318

Cooperation

Partners

Dr. Anika Friese / Prof. Dr. Uwe Rösler, Institute for Animal Hygiene and Environmental Health, Freie Universität Berlin

Dr. Greta Gölz / Prof. Dr. Thomas Alter, Institute of Food Safety and Food Hygiene, Freie Universität Berlin

Dr. Kerstin Stingl, National Reference Laboratory for Campylobacter, Federal Institute for Risk Assessment, Berlin

Dr. Sophie Kittler / Dr. Felix Reich / Prof. Dr. Corinna Kehrenberg, Institute for Food Quality and Food Safety, University of Veterinary Medicine Hanover

Dr. Michael Südbeck, Lohmann & Co. AG

PD Dr. Markus M. Heimesaat / Prof. Dr. Stefan Bereswill, Institute of Microbiology and Hygiene, Charité - University Medicine Berlin

PD Dr. Roland Bücker / Prof. Dr. Jörg Schulzke, Institute of Clinical Physiology, Charité - University Medicine Berlin

Prof. Dr. Steffen Backert, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nuremberg, Erlangen

PD Dr. Roswitha Merle, Institute for Veterinary Epidemiology and Biostatistics, Freie Universität Berlin

Torsten Semmler, Junior Research Group Microbial Genomics, Robert Koch Institute, Berlin

 

National and international collaboration

Leading experts in their specific fields of competence in Campylobacter research have agreed on joining the consortium as Associated Partners to provide expertise or support our work.

Associated Partners:

Dr. Bettina Rosner, Robert Koch Institute, Berlin

Dr. Monika Matt, AGES, Austria

Dr. Thomas Janning,  German Poultry Association, Berlin

Dr. Martin Eisenblätter, Synlab Berlin-Brandenburg, Berlin

Dr. Christine Bauermann, MVZ Labor Limbach Berlin

Prof. Dr. Ralf Ignatius, Labor 28 GmbH, Berlin

Dr. Klaus Pietsch, CVUA, Freiburg

Dr. Stefan Hertwig, Federal Institute for Risk Assessment, Berlin

Dr. Niels Bandick, Federal Institute for Risk Assessment, Berlin

Prof. Dr. Xiaonan Lu, University of British Columbia (UBC), Vancouver, Canada

Prof. Dr. Georgina Hold, University of Aberdeen, Scotland, UK

Dr. Ingrid Huber / Dr. Ute Messelhäußer, LGL, Oberschleißheim